Service A / Service B
About 25,000 km or 1 year (ASSYST)
25 000 km
12 months
Oil and filter at each service; Service B adds filters and wider checks. The ASSYST indicator prevails.
Source [1]W221 · 2010–2013
Mercedes Classe S S 350 W221 · 306 hp (2010 to 2013)
The Mercedes Classe S S 350 of the W221 generation uses the M276 3.5 V6 petrol engine with 306 hp.
Choose an engine
Identify the car and prepare its maintenanceTechnical specifications
- Fuel
- Petrol
- Power
- 306 PS / 225 kW
- Displacement
- 3 498 cm³
- Cylinders
- 6
- Engine code
- M276 3.5 V6
- Period covered
- 2010–2013
- Documented market
- Europe
Transmission
- Automatic · 7 speeds
Figures apply to the cited configuration and market; equipment and transmissions may vary by production date.
Specification source : [1] AutoKarnet
This version
306 hp (225 kW), rear-wheel drive, 7-speed automatic. Built from 2010 to 2013.
AutoKarnet advice
In the range
It sits between the S 400 Hybrid (299 hp) and the S 500 (388 hp). It replaces the 272 hp version built until 2010. The M276 3.5 V6 engine is also fitted to: Mercedes Classe C (W204), Mercedes Classe E (W212), Mercedes CLS (C218), Mercedes GLE / ML (ML / GLE W166), Mercedes SLK / SLC (SLK / SLC R172).
AutoKarnet advice
Maintenance and records
Brake fluid
Every 24 months
24 months
Time-based replacement, whatever the mileage.
Source [1]Questions about this version (2)
Which engine is in the Mercedes Classe S S 350 W221?
The M276 3.5 V6 petrol engine (3 498 cc), 306 hp (225 kW).
AutoKarnet advice
Which oil for the Mercedes Classe S S 350?
A MB 229.5 / 229.51 / 229.52-approved oil suited to the M276 3.5 V6 engine.
AutoKarnet advice
Documentary sources
- [1] Rédaction AutoKarnet
AutoKarnet · FR · Europe · Synthèse éditoriale AutoKarnet · Accessed 09/10/2026